Hi Josh,
This is a pretty open question, since you didn't specify the process. But if you are looking for a general answer, then the answer is yes, of course.
Any physical system contains a pile of information (describing, for example, the positions and momentums of the particles, or for larger systems more complicated information).
Depending on how you measure it, you can extract various kinds of information; I don't think such a process requires E = mc^2 or Landauer's principle.
David Schmid
(published on 04/21/2014)